Genomic Profiling on an Unselected Solid Tumor Population Reveals a Highly Mutated Wnt/β-Catenin Pathway Associated with Oncogenic EGFR Mutations

Oncogenic epidermal growth factor receptors (EGFRs) can recruit key effectors in diverse cellular processes to propagate oncogenic signals. Targeted and combinational therapeutic strategies have been successfully applied for treating EGFR-driven cancers. However, a main challenge in EGFR therapies i...

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Vydáno v:J Pers Med
Hlavní autoři: Jiang, Jingrui, Protopopov, Alexei, Sun, Ruobai, Lyle, Stephen, Russell, Meaghan
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023530/
https://ncbi.nlm.nih.gov/pubmed/29642553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm8020013
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