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Scalable preprocessing for sparse scRNA-seq data exploiting prior knowledge

MOTIVATION: Single cell RNA-seq (scRNA-seq) data contains a wealth of information which has to be inferred computationally from the observed sequencing reads. As the ability to sequence more cells improves rapidly, existing computational tools suffer from three problems. (i) The decreased reads-per-...

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Dettagli Bibliografici
Pubblicato in:Bioinformatics
Autori principali: Mukherjee, Sumit, Zhang, Yue, Fan, Joshua, Seelig, Georg, Kannan, Sreeram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022691/
https://ncbi.nlm.nih.gov/pubmed/29949988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty293
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