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Improved pathway reconstruction from RNA interference screens by exploiting off-target effects
MOTIVATION: Pathway reconstruction has proven to be an indispensable tool for analyzing the molecular mechanisms of signal transduction underlying cell function. Nested effects models (NEMs) are a class of probabilistic graphical models designed to reconstruct signalling pathways from high-dimension...
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Publicado no: | Bioinformatics |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6022657/ https://ncbi.nlm.nih.gov/pubmed/29950000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty240 |
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