Improved pathway reconstruction from RNA interference screens by exploiting off-target effects

MOTIVATION: Pathway reconstruction has proven to be an indispensable tool for analyzing the molecular mechanisms of signal transduction underlying cell function. Nested effects models (NEMs) are a class of probabilistic graphical models designed to reconstruct signalling pathways from high-dimension...

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Bibliografiska uppgifter
I publikationen:Bioinformatics
Huvudupphovsmän: Srivatsa, Sumana, Kuipers, Jack, Schmich, Fabian, Eicher, Simone, Emmenlauer, Mario, Dehio, Christoph, Beerenwinkel, Niko
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Ismb 2018–Intelligent Systems for Molecular Biology Proceedings
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022657/
https://ncbi.nlm.nih.gov/pubmed/29950000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty240
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