Interferon Signaling Is Frequently Downregulated in Melanoma

Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15–40% of melanoma patients and resistance is associated with defects in antigen presentation a...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Alavi, Sara, Stewart, Ashleigh Jacqueline, Kefford, Richard F., Lim, Su Yin, Shklovskaya, Elena, Rizos, Helen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021492/
https://ncbi.nlm.nih.gov/pubmed/29977240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01414
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