Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System(®) (RTS(®)) gene switch as gene therapy for the treatment of glioma

The purpose of this study was to determine if localized delivery of IL-12 encoded by a replication-incompetent adenoviral vector engineered to express IL-12 via a RheoSwitch Therapeutic System(®) (RTS(®)) gene switch (Ad-RTS-IL-12) administered intratumorally which is inducibly controlled by the ora...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Principais autores: Barrett, John A., Cai, Hongliang, Miao, John, Khare, Pranay D., Gonzalez, Paul, Dalsing-Hernandez, Jessica, Sharma, Geeta, Chan, Tim, Cooper, Laurence J.N, Lebel, Francois
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021367/
https://ncbi.nlm.nih.gov/pubmed/29755109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-018-0019-0
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