Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells

BACKGROUND: Abnormal pre-mRNA splicing regulation is common in cancer, but the effects of chemotherapy on this process remain unclear. METHODS: To evaluate the effect of chemotherapy on slicing regulation, we performed meta-analyses of previously published transcriptomic, proteomic, phosphoproteomic...

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Pubblicato in:Genome Med
Autori principali: Anufrieva, Ksenia S., Shender, Victoria О., Arapidi, Georgij P., Pavlyukov, Marat S., Shakhparonov, Michail I., Shnaider, Polina V., Butenko, Ivan O., Lagarkova, Maria A., Govorun, Vadim M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020472/
https://ncbi.nlm.nih.gov/pubmed/29950180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0557-y
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