Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-region. Thus far, studies have focused solely on the α-GDNF...

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Bibliographic Details
Published in:Front Neurol
Main Authors: Penttinen, Anna-Maija, Parkkinen, Ilmari, Voutilainen, Merja H., Koskela, Maryna, Bäck, Susanne, Their, Anna, Richie, Christopher T., Domanskyi, Andrii, Harvey, Brandon K., Tuominen, Raimo K., Nevalaita, Liina, Saarma, Mart, Airavaara, Mikko
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neurology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019446/
https://ncbi.nlm.nih.gov/pubmed/29973907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00457
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