IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways

Osteoarthritic chondrocytes secrete matrix metalloproteinase-13 (MMP-13) in response to interleukin-1 (IL-1), causing digestion of type II collagen in cartilage. Using chondrocytic cells, we previously determined that IL-1 induced a strong MMP-13 transcriptional response that requires p38 MAPK, JNK...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Mengshol, John A., Vincenti, Matthew P., Brinckerhoff, Constance E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60184/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11691923/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.21.4361
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