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Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling
The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coupling reaction provided generally the para-substitu...
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| Publicat a: | Molecules |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6017724/ https://ncbi.nlm.nih.gov/pubmed/29329219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23010149 |
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