Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

BACKGROUND: Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone resorption associated with osteolysis and the damag...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Yan, Zhao, Tian, Xiaoxi, Zhu, Jinyu, Lu, Zifan, Yu, Lifeng, Zhang, Dawei, Liu, Yanwu, Yang, Chongfei, Zhu, Qingsheng, Cao, Xiaorui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016863/
https://ncbi.nlm.nih.gov/pubmed/30134793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-018-0013-x
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