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C1q-binding anti-HLA antibodies do not predict platelet transfusion failure in TRAP study participants

BACKGROUND: In the Trial to Reduce Alloimmunization to Platelets (TRAP) study, 101 of 530 subjects became clinically refractory (CR) to platelets without lymphocytotoxicity assay (LCA) detectable anti-HLA antibodies. The LCA only detects complement-binding antibodies, and is less sensitive than newe...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Jackman, Rachael P., Lee, Jar-How, Pei, Rui, Bolgiano, Douglas, Lebedeva, Mila, Slichter, Sherrill J., Norris, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016838/
https://ncbi.nlm.nih.gov/pubmed/27079754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.13598
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