Metabolites of n-Butylparaben and iso-Butylparaben Exhibit Estrogenic Properties in MCF-7 and T47D Human Breast Cancer Cell Lines

Two oxidized metabolites of n-butylparaben (BuP) and iso-butylparaben (IsoBuP) discovered in human urine samples exhibit structural similarity to endogenous estrogens. We hypothesized that these metabolites bind to the human estrogen receptor (ER) and promote estrogen signaling. We tested this using...

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Publicado en:Toxicol Sci
Autores principales: Gonzalez, Thomas L, Moos, Rebecca K, Gersch, Christina L, Johnson, Michael D, Richardson, Rudy J, Koch, Holger M, Rae, James M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Paraben Metabolites and Estrogenic Effects in Cell Lines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016648/
https://ncbi.nlm.nih.gov/pubmed/29945225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy063
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