Tolerance to high‐internalizing δ opioid receptor agonist is critically mediated by arrestin 2

BACKGROUND AND PURPOSE: Opioid δ receptor agonists are potent antihyperalgesics in chronic pain models, but tolerance develops after prolonged use. Previous evidence indicates that distinct forms of tolerance occur depending on the internalization properties of δ receptor agonists. As arrestins are...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Vicente‐Sanchez, Ana, Dripps, Isaac J, Tipton, Alycia F, Akbari, Heba, Akbari, Areeb, Jutkiewicz, Emily M, Pradhan, Amynah A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016618/
https://ncbi.nlm.nih.gov/pubmed/29722902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14353
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