Low-density lipoprotein receptor–related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression

Reduced low-density lipoprotein receptor–related protein-1 (LRP1) expression in the liver is associated with poor prognosis of liver cirrhosis and hepatocellular carcinoma. Previous studies have shown that hepatic LRP1 deficiency exacerbates palmitate-induced steatosis and toxicity in vitro and also...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Hamlin, Allyson N., Chinnarasu, Sivaprakasam, Ding, Yinyuan, Xian, Xunde, Herz, Joachim, Jaeschke, Anja, Hui, David Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016462/
https://ncbi.nlm.nih.gov/pubmed/29752404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001952
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