Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells

Loss of CD28 is a characteristic feature of T cell aging, but the underlying mechanisms of this loss are elusive. As differential expression of microRNAs (miRNAs) has been described between CD28+ and CD28− T cells, we hypothesized that altered miRNA expression contributes to the age-associated downr...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Teteloshvili, Nato, Dekkema, Gerjan, Boots, Annemieke M., Heeringa, Peter, Jellema, Pytrick, de Jong, Debora, Terpstra, Martijn, Brouwer, Elisabeth, Pawelec, Graham, Kok, Klaas, van den Berg, Anke, Kluiver, Joost, Kroesen, Bart-Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015875/
https://ncbi.nlm.nih.gov/pubmed/29967621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01400
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