Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes

Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the accompanying inflammation. Here we show that exposure of primary cardiomy...

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Udgivet i:Cell Death Differ
Main Authors: Deshwal, Soni, Forkink, Marleen, Hu, Chou-Hui, Buonincontri, Guido, Antonucci, Salvatore, Di Sante, Moises, Murphy, Michael P, Paolocci, Nazareno, Mochly-Rosen, Daria, Krieg, Thomas, Di Lisa, Fabio, Kaludercic, Nina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015497/
https://ncbi.nlm.nih.gov/pubmed/29459772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0071-1
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