TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

Inflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role of TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration of substantia nigra dopamine neurons (DNs). TLR9 agonist, CpG-ODN, induced DN degeneration in mice lacking GR in microglia but not i...

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Publié dans:Nat Commun
Auteurs principaux: Maatouk, Layal, Compagnion, Anne-Claire, Sauvage, Maria-Angeles Carrillo-de, Bemelmans, Alexis-Pierre, Leclere-Turbant, Sabrina, Cirotteau, Vincent, Tohme, Mira, Beke, Allen, Trichet, Michaël, Bazin, Virginie, Trawick, Bobby N., Ransohoff, Richard M., Tronche, François, Manoury, Bénédicte, Vyas, Sheela
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015079/
https://ncbi.nlm.nih.gov/pubmed/29934589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04569-y
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