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Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns

Endothelial cells adopt unique cell fates during sprouting angiogenesis, differentiating into tip or stalk cells. The fate selection process is directed by Delta-Notch lateral inhibition pathway. Classical Delta-Notch models produce a spatial pattern of tip cells separated by a single stalk cell, or...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Koon, Yen Ling, Zhang, Songjing, Rahmat, Muhammad Bakhait, Koh, Cheng Gee, Chiam, Keng-Hwee
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015056/
https://ncbi.nlm.nih.gov/pubmed/29934586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27645-1
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