Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose denosumab in healthy Chinese volunteers: A randomized, single-blind, placebo-controlled study

BACKGROUND: Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, a cytokine essential for the formation, function and survival of osteoclasts. This study assessed the pharmacokinetics, pharmacodynamics, safety and tolerability of single-dose den...

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Vydáno v:PLoS One
Hlavní autoři: Chen, Qian, Hu, Chaoying, Liu, Yanmei, Song, Rong, Zhu, Wenjing, Zhao, Hongxin, Nino, Antonio, Zhang, Fan, Liu, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014657/
https://ncbi.nlm.nih.gov/pubmed/29933364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197984
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