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Expeditious synthesis of the fused hexacycle of puberuline C via a radical-based cyclization/translocation/cyclization process

The fused 6/7/5/6/6/6-hexacyclic ring system of puberuline C was assembled in 18 steps from 2-(ethoxycarbonyl)cyclohexanone. After the azabicyclo[3.3.1]nonane derivative was sequentially coupled with propargyl magnesium bromide, 2-iodo cyclopentenone and allyl bromide, the pentacycle was constructed...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Hagiwara, Koichi, Tabuchi, Toshiki, Urabe, Daisuke, Inoue, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014077/
https://ncbi.nlm.nih.gov/pubmed/30155084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00671j
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