Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ

Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of renal fibrosis. Runt-related transcription factor 1(RUNX1) plays a vital role in hematopoiesis via Endothelial-to-Hematop...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Zhou, Tong, Luo, Maocai, Cai, Wei, Zhou, Siyuan, Feng, Danying, Xu, Chundi, Wang, Hongyan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013935/
https://ncbi.nlm.nih.gov/pubmed/29759484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.04.023
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