Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyt...

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Vydáno v:EBioMedicine
Hlavní autoři: Zhang, Song-Yang, Dong, Yong-Qiang, Wang, Pengcheng, Zhang, Xingzhong, Yan, Yu, Sun, Lulu, Liu, Bo, Zhang, Dafang, Zhang, Heng, Liu, Huiying, Kong, Wei, Hu, Gang, Shah, Yatrik M., Gonzalez, Frank J., Wang, Xian, Jiang, Changtao
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013933/
https://ncbi.nlm.nih.gov/pubmed/29735414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.04.022
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