Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity

The process of epithelial–mesenchymal transition (EMT) of lens epithelial cells (LECs) after cataract surgery contributes to tissue fibrosis, wound healing and lens regeneration via a mechanism not yet fully understood. Here, we show that tropomyosin 2 (Tpm2) plays a critical role in wound healing a...

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Pubblicato in:Mech Ageing Dev
Autori principali: Shibata, Teppei, Shibata, Shinsuke, Ishigaki, Yasuhito, Kiyokawa, Etsuko, Ikawa, Masahito, Singh, Dhirendra P., Sasaki, Hiroshi, Kubo, Eri
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013838/
https://ncbi.nlm.nih.gov/pubmed/29510160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2018.03.001
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