A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval as a treatment for acute heart failure. The diverse effects of H2 relaxin are mediated via its cognate G protein co...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T., Royce, Simon G., Nair, Vinojini B., Siwek, Christopher, Patil, Nitin A., Harrison, Ian P., Rosengren, K. Johan, Selemidis, Stavros, Summers, Roger J., Wade, John D., Bathgate, Ross A. D., Samuel, Chrishan S.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013806/
https://ncbi.nlm.nih.gov/pubmed/30155023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04754d
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