A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval as a treatment for acute heart failure. The diverse effects of H2 relaxin are mediated via its cognate G protein co...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T., Royce, Simon G., Nair, Vinojini B., Siwek, Christopher, Patil, Nitin A., Harrison, Ian P., Rosengren, K. Johan, Selemidis, Stavros, Summers, Roger J., Wade, John D., Bathgate, Ross A. D., Samuel, Chrishan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013806/
https://ncbi.nlm.nih.gov/pubmed/30155023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04754d
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