PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis

Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It is highly expressed in alveolar macrophages (AMs), which are unable to clear the intracellular pathogen Mycobacterium tuberculosis (M.tb). Although M.tb infection in...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Arnett, Eusondia, Weaver, Ashlee M., Woodyard, Kiersten C., Montoya, Maria J., Li, Michael, Hoang, Ky V., Hayhurst, Andrew, Azad, Abul K., Schlesinger, Larry S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013021/
https://ncbi.nlm.nih.gov/pubmed/29928066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007100
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