IMMU-08. PHASE I TRIAL (NCT02457845) SAFETY, TOLERABILITY AND PRELIMINARY EFFICACY OF IMMUNOVIROTHERAPY WITH HSV G207 IN CHILDREN WITH PROGRESSIVE MALIGNANT SUPRATENTORIAL BRAIN TUMORS

BACKGROUND: Outcomes for children with progressive malignant supratentorial brain tumors are dismal. Preclinical evidence indicates that pediatric brain tumors are highly sensitive to genetically engineered oncolytic HSV-1 G207, which lacks genes essential for replication in normal brain. We report...

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Vydáno v:Neuro Oncol
Hlavní autoři: Friedman, Gregory, Bag, Asim, Madan-Swain, Avi, Li, Rong, Kachurak, Kara, Osorio, Diana, Hukin, Juliette, Martin, Allison, Pastakia, Devang, Karajannis, Matthias, Bernstock, Joshua, Fiveash, John, Reddy, Alyssa, Whitley, Richard, Gillespie, Yancey, Markert, James, Johnston, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012830/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.324
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