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Brain-specific expression of an exogenous gene after i.v. administration

The treatment of brain diseases with gene therapy requires the gene to be expressed throughout the central nervous system, and this is possible by using gene targeting technology that delivers the gene across the blood–brain barrier after i.v. administration of a nonviral formulation of the gene. Th...

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Autori principali: Shi, Ningya, Zhang, Yun, Zhu, Chunni, Boado, Ruben J., Pardridge, William M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC60126/
https://ncbi.nlm.nih.gov/pubmed/11592987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221450098
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