Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7

The excessive production of type I IFNs is a hallmark and a main pathogenic mechanism of many autoimmune diseases, including systemic lupus erythematosus (SLE). In these pathologies, the sustained secretion of type I IFNs is dependent on the improper activation of plasmacytoid DCs (pDCs) by self–nuc...

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Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Salvi, Valentina, Gianello, Veronica, Busatto, Sara, Bergese, Paolo, Andreoli, Laura, D’Oro, Ugo, Zingoni, Alessandra, Tincani, Angela, Sozzani, Silvano, Bosisio, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012509/
https://ncbi.nlm.nih.gov/pubmed/29769437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98204
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