PHRM-03. CEREBROSPINAL FLUID PENETRATION OF PEXIDARTINIB (PLX3397), A CSF1R INHIBITOR, IN A NONHUMAN PRIMATE MODEL

BACKGROUND: Pexidartinib (PLX3397) is a colony stimulating factor-1 receptor (CSF1R) inhibitor under clinical evaluation including potential CNS tumor treatment. This study aims to estimate CNS penetration of pexidartinib in a nonhuman primate (NHP) CSF Reservoir model. METHODS: 4 male rhesus macaqu...

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Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Odabas, Arman, McCully, Cynthia M Lester, Cruz, Rafael, Figg, William D, Glod, John, Rymar, Andrey, Peer, Cody, Warren, Katherine E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012252/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.581
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