DIPG-25. A KINOME-WIDE shRNA SCREEN UNCOVERS VRK3 AS AN ESSENTIAL GENE FOR DIPG SURVIVAL

Diffuse Intrinsic Pontine Glioma (DIPG) remains the most fatal form of pediatric brain tumor. The specific somatic mutation (H3K27M) in the H3 histone gene was found in around 95% of patients making this alteration as the initial oncogenic event. However, until now this alteration cannot be targeted...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Evangelista, Cláudia CS, Barret, Emilie, Merlevede, Jane, Saccasyn, Ambre, Puget, Stéphanie, Grill, Jacques, Castel, David, Debily, Marie-Anne
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012151/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.118
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