MBRS-37. IN VITRO MODELLING OF TUMOUR EVOLUTION AND RADIOTHERAPY RESISTANCE IN MEDULLOBLASTOMA

Medulloblastoma relapse occurs in 30-40% of patients, is almost universally fatal and accounts for ~10% of childhood cancer deaths. Acquisition of combined MYC/MYCN and TP53 defects occurs in 30% of recurrences following standard-upfront-treatment. Therapy-related selection pressure plays a role in...

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Publicado en:Neuro Oncol
Autores principales: Richardson, Stacey, Hill, Rebecca, Selby, Matthew, Lindsey, Janet, Rafiee, Gholamreza, Bailey, Simon, Williamson, Daniel, Clifford, Steve
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012067/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.482
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