Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice

We used NOD/SCID mice, also known as NRG, to assess the ability of lentivirus-mediated intravenous delivery of CRISPR in editing the HIV-1 genome from the circulating PBMC engrafts, some of which homed within several animal solid tissues. Lentivirus-mediated delivery of a multiplex of guide RNAs acc...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Bella, Ramona, Kaminski, Rafal, Mancuso, Pietro, Young, Won-Bin, Chen, Chen, Sariyer, Rahsan, Fischer, Tracy, Amini, Shohreh, Ferrante, Pasquale, Jacobson, Jeffrey M., Kashanchi, Fatah, Khalili, Kamel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011019/
https://ncbi.nlm.nih.gov/pubmed/30195766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.05.021
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