Durable engraftment of genetically modified FVIII‐secreting autologous bone marrow stromal cells in the intramedullary microenvironment

Genetically modified FVIII‐expressing autologous bone marrow‐derived mesenchymal stromal cells (BMSCs) could cure haemophilia A. However, culture‐expanded BMSCs engraft poorly in extramedullary sites. Here, we compared the intramedullary cavity, skeletal muscle, subcutaneous tissue and systemic circ...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Cell Mol Med
Päätekijät: Lee, Sze Sing, Sivalingam, Jaichandran, Nirmal, Ajit J., Ng, Wai Har, Kee, Irene, Song, In Chin, Kiong, Chin Yong, Gales, Kristoffer A., Chua, Frederic, Pena, Edgar M., Ogden, Bryan E., Kon, Oi Lian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2018
Aiheet:
Short Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010829/
https://ncbi.nlm.nih.gov/pubmed/29682884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13648
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