C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory IFN-γ activation of macrophages driven by macropha...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Dufour, Antoine, Bellac, Caroline L., Eckhard, Ulrich, Solis, Nestor, Klein, Theo, Kappelhoff, Reinhild, Fortelny, Nikolaus, Jobin, Parker, Rozmus, Jacob, Mark, Jennifer, Pavlidis, Paul, Dive, Vincent, Barbour, Sean J., Overall, Christopher M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010466/
https://ncbi.nlm.nih.gov/pubmed/29925830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04717-4
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