Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal chemotherapy regimes, with almost half of patients expected to develop congestive heart failure given high doses. However, the genetic basis of sensitivity to anthracyclines remains unclear. We created a panel of...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Knowles, David A, Burrows, Courtney K, Blischak, John D, Patterson, Kristen M, Serie, Daniel J, Norton, Nadine, Ober, Carole, Pritchard, Jonathan K, Gilad, Yoav
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Genetics and Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010343/
https://ncbi.nlm.nih.gov/pubmed/29737278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33480
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