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A Randomized Clinical Trial of Metformin to treat Autosomal Dominant Polycystic Kidney Disease
BACKGROUND: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic ki...
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| Publicado no: | Am J Nephrol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010317/ https://ncbi.nlm.nih.gov/pubmed/29779024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000488807 |
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