Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...

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Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: de Medeiros, Amanda Fernandes, Costa, Izael de Sousa, de Carvalho, Fabiana Maria Coimbra, Kiyota, Sumika, de Souza, Beatriz Blenda Pinheiro, Sifuentes, Daniel Nogoceke, Serquiz, Raphael Paschoal, Maciel, Bruna Leal Lima, Uchôa, Adriana Ferreira, dos Santos, Elizeu Antunes, Morais, Ana Heloneida de Araújo
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010142/
https://ncbi.nlm.nih.gov/pubmed/29322840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419220
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