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Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: de Medeiros, Amanda Fernandes, Costa, Izael de Sousa, de Carvalho, Fabiana Maria Coimbra, Kiyota, Sumika, de Souza, Beatriz Blenda Pinheiro, Sifuentes, Daniel Nogoceke, Serquiz, Raphael Paschoal, Maciel, Bruna Leal Lima, Uchôa, Adriana Ferreira, dos Santos, Elizeu Antunes, Morais, Ana Heloneida de Araújo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010142/
https://ncbi.nlm.nih.gov/pubmed/29322840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419220
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