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Structure–activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid

In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d–6g, 10d–12g, 16d–18g and 22d–24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of a...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Gao, Xiaohui, Tang, Jingjing, Liu, Haoran, Liu, Linbo, Kang, Lu, Chen, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010128/
https://ncbi.nlm.nih.gov/pubmed/29447012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1436053
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