Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies

A new series of NSAID thioesters were synthesized and evaluated for their in vitro antitumor effects against a panel of four human tumor cell lines, namely: HepG2, MCF-7, HCT-116 and Caco-2, using the MTT assay. Compared to the reference drugs 5-FU, afatinib and celecoxib, compounds 2b, 3b, 6a, 7a,...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., El-Husseiny, Walaa M., El_Morsy, Ahmad M., El-Gendy, Manal A., El-Sayed, Magda A.-A.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009944/
https://ncbi.nlm.nih.gov/pubmed/29806488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1474878
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