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Design, synthesis and biological activity of pyrazinamide derivatives for anti-Mycobacterium tuberculosis
A total of 11 pyrazinamide derivatives were designed and synthesised using pyrazinamide as the lead compound, which was optimised by structural modification with alkyl chains, six-membered rings, and bioisosterism, respectively. The target compounds were synthesised using pyrazinecarboxylic acid as...
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| Publicado no: | J Enzyme Inhib Med Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009857/ https://ncbi.nlm.nih.gov/pubmed/28870094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1367774 |
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