Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)

The GTPase EF-Tu in ternary complex with GTP and aminoacyl-tRNA (aa-tRNA) promotes rapid and accurate delivery of cognate aa-tRNAs to the ribosomal A site. Here we used cryo-EM to study the molecular origins of the accuracy of ribosome-aided recognition of a cognate ternary complex and the accuracy-...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Fislage, Marcus, Zhang, Jingji, Brown, Zuben Patrick, Mandava, Chandra Sekhar, Sanyal, Suparna, Ehrenberg, Måns, Frank, Joachim
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009598/
https://ncbi.nlm.nih.gov/pubmed/29733411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky346
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