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Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pul...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008587/ https://ncbi.nlm.nih.gov/pubmed/29997860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04133c |
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