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Signature of Antibody Domain-Exchange by Native Mass Spectrometry and Collision Induced Unfolding
The development of domain-exchanged antibodies offers a route to high affinity targeting to clustered multivalent epitopes, such as those associated with viral infections and many cancers. One strategy to generate these antibodies is to introduce mutations into target antibodies to drive domain-exch...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008249/ https://ncbi.nlm.nih.gov/pubmed/29757629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00573 |
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