Regulation of Eag by Ca(2+)/calmodulin controls presynaptic excitability in Drosophila

Drosophila ether-à-go-go (eag) is the founding member of a large family of voltage-gated K(+) channels, the KCNH family, which includes Kv10, 11, and 12. Concurrent binding of calcium/calmodulin (Ca(2+)/CaM) to NH(2)- and COOH-terminal sites inhibits mammalian EAG1 channels at submicromolar Ca(2+) c...

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Udgivet i:J Neurophysiol
Main Authors: Bronk, Peter, Kuklin, Elena A., Gorur-Shandilya, Srinivas, Liu, Chang, Wiggin, Timothy D., Reed, Martha L., Marder, Eve, Griffith, Leslie C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008097/
https://ncbi.nlm.nih.gov/pubmed/29364071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00820.2017
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