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Anti-cancer binary system activated by bacteriophage HK022 integrase
The binary system presented in this work is based on the bacteriophage HK022 integrase recombinase that activates the expression of a silenced Diphtheria toxin gene, both controlled by the cancer specific hTERT promoter. Using a lung cancer mice model, assays of different apoptotic and anti-apoptoti...
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| 發表在: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Impact Journals LLC
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007955/ https://ncbi.nlm.nih.gov/pubmed/29938000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25512 |
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