Improving RNA nearest neighbor parameters for helices by going beyond the two-state model

RNA folding free energy change nearest neighbor parameters are widely used to predict folding stabilities of secondary structures. They were determined by linear regression to datasets of optical melting experiments on small model systems. Traditionally, the optical melting experiments are analyzed...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Spasic, Aleksandar, Berger, Kyle D, Chen, Jonathan L, Seetin, Matthew G, Turner, Douglas H, Mathews, David H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007268/
https://ncbi.nlm.nih.gov/pubmed/29718397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky270
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