Improving RNA nearest neighbor parameters for helices by going beyond the two-state model

RNA folding free energy change nearest neighbor parameters are widely used to predict folding stabilities of secondary structures. They were determined by linear regression to datasets of optical melting experiments on small model systems. Traditionally, the optical melting experiments are analyzed...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Spasic, Aleksandar, Berger, Kyle D, Chen, Jonathan L, Seetin, Matthew G, Turner, Douglas H, Mathews, David H
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Computational Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007268/
https://ncbi.nlm.nih.gov/pubmed/29718397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky270
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