How to address the challenges of evaluating treatment benefits-risks in rare diseases? A convergent mixed methods approach applied within a Merkel cell carcinoma phase 2 clinical trial

BACKGROUND: Demonstrating treatment benefits within clinical trials in the context of rare diseases is often methodologically and practically challenging. Mixed methods research offers an approach to overcome these challenges by combining quantitative and qualitative data, thus providing a better un...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Bharmal, Murtuza, Guillemin, Isabelle, Marrel, Alexia, Arnould, Benoit, Lambert, Jérémy, Hennessy, Meliessa, Fofana, Fatoumata
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006962/
https://ncbi.nlm.nih.gov/pubmed/29914528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-018-0835-1
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