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Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma

BACKGROUND: The mechanism underlying chromosome rearrangement in nasopharyngeal carcinoma (NPC) remains elusive. It is known that most of the aetiological factors of NPC trigger oxidative stress. Oxidative stress is a potent apoptotic inducer. During apoptosis, chromatin cleavage and DNA fragmentati...

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Detalhes bibliográficos
Publicado no:Hum Genomics
Main Authors: Tan, Sang-Nee, Sim, Sai-Peng, Khoo, Alan Soo-Beng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006577/
https://ncbi.nlm.nih.gov/pubmed/29914565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-018-0160-8
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