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Performance of epistasis detection methods in semi-simulated GWAS

BACKGROUND: Part of the missing heritability in Genome Wide Association Studies (GWAS) is expected to be explained by interactions between genetic variants, also called epistasis. Various statistical methods have been developed to detect epistasis in case-control GWAS. These methods face major stati...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Chatelain, Clément, Durand, Guillermo, Thuillier, Vincent, Augé, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006572/
https://ncbi.nlm.nih.gov/pubmed/29914375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2229-8
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